MEWIGEN Microsatellite Analysis
In order to estimate the probability of mutations in mismatch repair genes in patients with Lynch syndrome-associated cancers.
We offer a PCR-based analysis of the Bethesda markers in tumor tissue and corresponding normal tissue. High microsatellite instability (MSI-H) indicate mismatch repair (MMR) deficiency based either on somatic or on germline mutations in respective genes, whereby the latter proves a Lynch syndrome.
Method:
Fluorescence-based fragment length analyses
Turnaround time:
3 weeks
Specimen requirements:
DNA from tumor tissue and, if possible, from paired normal tissue
Please contact us beforehand if you want us to isolate DNA from tumor and/or normal tissue.